Oral Presentation Clinical Oncology Society of Australia Annual Scientific Meeting 2024

Patient Reported Measures as the Optimal Assessment of Chemotherapy-Induced Peripheral Neuropathy (#79)

Tiffany Li 1 , Hannah C Timmins 2 , Fawaz M Mahfouz 1 , Terry Trinh 2 , David Mizrahi 1 , Lisa G Horvath 3 , Michelle Harrison 3 , Peter Grimison 3 , Michael Friedlander 4 , Gavin Marx 5 , Frances Boyle 6 , David Wyld 7 , Robert Henderson 7 , Tracy King 8 , Sally Baron-Hay 9 , Matthew C Kiernan 2 , Claudia Rutherford 1 , David Goldstein 10 , Susanna B Park 1
  1. Faculty of Medicine and Health, University of Sydney, Sydney
  2. Neuroscience Research Australia, Randwick
  3. Chris O’Brien Lifehouse, Camperdown
  4. Prince of Wales Hospital, Randwick
  5. Sydney Adventist Hospital, Wahroonga
  6. Mater Hospital, North Sydney
  7. The University of Queensland, Brisbane
  8. Institute of Haematology, Royal Prince Alfred Hospital, Camperdown
  9. Royal North Shore Hospital, St Leonards
  10. Prince of Wales Clinical School, UNSW, Kensington

Introduction

Chemotherapy-induced peripheral neurotoxicity (CIPN) is a significant and persisting toxicity of anticancer treatments, impacting dose delivery and quality of life. There is a lack of consensus on the optimal method of CIPN assessment in clinical settings. This study compared the validity and responsiveness of patient reported outcome measures (PROMs) against neurological, neurophysiological and sensory assessment approaches of CIPN.

Methods

A multi-center dual study design evaluated patients treated with neurotoxic chemotherapy across two cohorts: patients commencing treatment assessed prospectively and patients who completed treatment assessed cross-sectionally. CIPN was assessed via PROMs (EORTC-CIPN20, FACT/GOG-Ntx, PRO-CTCAE), neurological and neurophysiological assessment (Total Neuropathy Score, sural and tibial compound nerve amplitudes) and sensory functional measures (Grating orientation, Von Frey monofilament and 2-Point discrimination tasks). Convergent and known-groups validity were assessed cross-sectionally following treatment completion and responsiveness was evaluated prospectively during treatment. Neurological, neurophysiological, and sensory outcome measure scores were compared between high and low CIPN symptom reporters.

Results

A total of 1,033 patients were recruited, incorporating 1,623 assessments. PROMs demonstrated superior ability to identify CIPN (convergent validity; α=0.75-0.85, all P<0.001), to discriminate between CIPN severity (known-groups validity; all P<0.001) and to detect changes in CIPN development (responsiveness; Cohen’s d=0.65-0.83) compared to neurological, neurophysiological and sensory assessment approaches. These other measures did not achieve threshold for convergent validity (α<0.7). and did not demonstrate acceptable responsiveness (Cohen’s d<0.5). Neurological, neurophysiological, and sensory outcome measures were significantly impaired in patients who were high CIPN symptom reporters compared to low (all P<0.05).

Conclusion

PROMs represent a valid method of CIPN assessment, with preferential measurement properties over other approaches to assessing neuropathy. Adoption of PROMs in clinical practice will allow for accurate representation and early recognition of CIPN, leading to reduced long term morbidity in this key long-term toxicity in cancer survivors.